4/13/26, 7:45pm

It’s dark outside, but the fluorescent lights are shining brightly inside the lab. The lab is made up of four separate bays, each containing two adjacent benches. Beside each bench, next to the window, is a desk, with a computer or laptop sitting on top. There’s a short chair in front of each desk and a tall chair in front of each bench. 

There are a few large pieces of equipment spread out through the lab. A large white slide scanner on the bench against the far wall, and a large black HPLC in the second bay of the lab when you enter the door. But mostly, the benches and the shelves above them are just full of bottles and boxes of pipette tips and various reagents. It’s a messy scene, but not because things are dirty or out of place. This is clearly a lab that is heavily in use. 

There’s only one lab member present at the moment. Navya. She’s sitting on the tall chair, in the second to last bay, hovering over the bench. She’s wearing a turquoise hoodie, pipette in hand. 

Navya’s benchtop is littered with bottles full of clear liquids, colorful tube racks lined with small and large tubes, two open cardboard kit boxes with reagents scattered about, a small beaker half full of discarded pipette tips, and lots more.

Navya has large black headphones on and doesn’t notice as Mike walks into the lab. Mike is wearing a dress shirt, untucked from his dark jeans. Coffee mug in hand. A lab no-no, but it’s late, and Mike doesn’t want to be too far away from his coffee. 

Mike approaches Navya’s bench slowly.

“Navi,” he says softly. No response.

He waves a hand in the air. Still no response.

“Navi,” he says louder. No response.

Suddenly, Navya sees Mike in her peripheral vision and jerks up, nearly falling off of her chair.

“Shit. You scared me.”

“I know,” Mike replies. “Sorry, I tried to…”

“I thought you’d left,” Navya says, as she lowers her headphones onto her neck.

“Just to grab some food. Grant’s due tomorrow. It’s gonna be a late night.”

“Ugh. That sucks. I’m almost done. I’m meeting a friend at…” Navya glances at her watch. “Shit!”

Navya abruptly stands up from the chair and starts scrambling. She discards her pipette tip and closes the open tubes. She packs up the kits, runs them over to the fridge, and shoves them in. She throws her tube rack full of small tubes into a small incubator on the adjacent bench. All while Mike is standing there, coffee mug still in hand.

“Bad time?” asks Mike.

“Sorry. It’s a new friend. I don’t want to be late. Well, I mean I don’t want to be too late.”

“No problem,” Mike responds.

“Was it something important?”

“No,” Mike says, half to himself. “Well, maybe. But it can wait.”

“Ok, sorry.”

Navya grabs her coat from her desk, throws her laptop in her backpack, and hurries past Mike.

“We’ll be alright,” Mike says quietly. “I have a good feeling about this one.”

“Great!” Navya responds, running out of the lab. “See you tomorrow!”

“Yes, see you tomorrow,” Mike says, his voice trailing off. He takes one last sip from his coffee mug and walks out of the now empty lab.

4/13/26, 7:45pm Read Post »

4/14/26, 10:25am

The lab is full today, with five lab members spread about the lab, some sitting at their desks, some working at their benches. 

Navya is back in her bay, sitting at her desk, typing away at her computer. Directly behind her, sitting back to back with her, is Chris, wearing a blue t-shirt, currently scrolling through his iPhone. 

“Did you hear what Trump posted?” Chris asks. “Such a jackass.”

“I really don’t want want to know.” Navya responds.

“He called the Pope weak on crime! I mean, for christ’s sake…literally!” 

“He just talks. I don’t know why you even pay attention anymore,” Navya responds. 

“Well, you know what they say about train crashes,” Chris says, still scrolling. “Except in this case, we’re all the passengers, and he’s the conductor.” 

Navya pulls up a powerpoint presentation on her computer.

“Hey, did you get that script working?” Navya asks.

“Oh yeah. ChatGPT baby. It runs like a charm now.”

“Great,” Navya exclaims. “What were the results?”

“Nothing significant.” Chris shrugs, closing the current app on his phone and opening another. 

“Damnit. Are you sure? What was the exact analysis you ran? Maybe…” 

At that moment, Ling steps into the bay wearing a labcoat. She’s followed close behind by a young man who is also wearing a labcoat…although he seems much less comfortable in the labcoat compared to Lin.

“Navi, Chris, I’d like to introduce you to Marcus.” 

Navya looks up from her computer. Chris keeps staring at his phone. 

“Hi Marcus, nice to meet you,” says Navya. 

“Yeah, good meeting you,” Chris chimes in.

“Marcus is the undergrad that Dr. Fein mentioned in lab meeting. I’m showing him around today, but we’re still figuring out who he should work with. Do you guys need help with anything?” 

“How do you feel about mousework?” Navya asks.

“Me?” Marcus replies shyly. “I guess that’s ok. Like living mice?”

Chris finally looks up from his phone. “Yeah, that’s the idea. Well, living right now. Less so once it’s time to collect their brains.” 

“Their brains?” asks Marcus.

“Yeah, that is how you study Alzheimer’s disease,” replies Chris. “You kinda have to look at the brain.”

“Oh,” replies Marcus nervously. “That makes sense.”

There’s a pause. Marcus is thinking, and Chris is happy to let him process the situation.

“Do I have to, like, touch them?” asks Marcus.

“Not with your hands, but we will need to use your teeth to get their heads off.”

“Chris!!” shouts Navya. “That really isn’t funny.”

Navya gets up and approaches Marcus.

“I assure you, we follow all of our animal protocols to the letter. You can join me this afternoon. Don’t worry…I’ll do all the mouse handling. You can just watch for now. If you feel comfortable later, you can help with some of the procedures.”

“Yeah, that sounds good. My mom is gonna flip when I tell her I worked with mice.”

“Yeah, it’s pretty interesting. And I’m really sorry about Chris. He’s a little off.”

“Welcome to the lab, Marcus!” shouts Chris.

“Um, thanks…” replies Marcus, as him and Ling walk over to the next bay.

“What the hell is wrong with you?” Navya chastises Chris, as she sits back down at her desk. 

“Sorry,” Chris responds. “I couldn’t resist.”

4/14/26, 10:25am Read Post »

4/14/26, 3:30pm

Navya and Marcus are in the back of the lab, next to the fume hood. Both are wearing lab coats and purple latex gloves. Navya places some blue pads down on the far bench and lays out some dissection tools. Marcus is bending down, his eyes staring directly into a small cage, watching two black mice run around.

“This is so wild.” Marcus says. “My mom’s gonna flip.”

“So where are you from, Marcus?” Navya asks, as she continues to prepare for the dissection.

“North Carolina. I actually spent a summer working in a lab at Duke when I was in High School. But they didn’t have any mice!”

“And how are you liking the big city?” Navya asks. “Quite the change from North Carolina.”

“Oh yeah,” Marcus replies. “NYC is built different, for sure. But I love it here. It’s impossible to be bored.”

“That’s great,” replies Navya. “Ok, I think we’re ready to start.”

Marcus stands up straight again and backs away from the mice.

“So we’re just gonna, like, kill them? Will they feel it?”

Navya removes the water bottle from the cage and places it down on the bench. Then she takes the cage lid off and places it on the bench. Then she tilts up the metal wire portion that holds the mouse food, so that she can reach the mice.

“We anesthetize them first,” Navya says, grabbing a mouse by its tail and placing it onto the metal wiring. “The small prick that it’s about to feel from this needle is the most pain it will feel.”

While still holding the mouse’s tail with her right hand, Navya scruffs the mouse with her left hand, placing her thumb and the knuckle of her index finger on the mouse’s neck and pinning it against the cage. Then she pinches the skin of the mouse’s neck tightly, grabs the tail with her right pinky, and lifts up the mouse, all in one swift motion. The mouse tries to wiggle it’s head left and right, but it’s completely immobilized.

“Wild,” Marcus repeats.

“You know, I spent all of grad school refusing to do mouse work,” Navya says, now picking up a syringe off the bench with her right hand. “I’m actually a vegan!”

“What changed?” asks Marcus.

“The science,” replies Navya. “I discovered an interesting signal in the entorhinal cortex of postmortem human brains. That’s a region that’s affected early in Alzheimer’s disease. I wanted to study if that signal is responsible for the Alzheimer’s pathology the develops in that region. But cells don’t have brain regions, so the only way to test my hypothesis is in mice.”

Navya carefully insert the needle of the syringe into the mouse’s abdomen. The mouse lets out a quick squeal.

“I’m sorry, buddy” Navya says to the mouse. Then she presses down on the syringe, injecting the ketamine/xylazine solution into the mouse’s abdomen. Navya withdraws the needs, places the syringe back down on the bench, and lifts up the wiring again. She then places her hand back into the cage and let’s the mouse go; the mouse quickly jumps forward and runs around the cage again.

“Now what?” asks Marcus.

“Now we wait,” replies Navya.

At that moment, Mike appears at the end of the bay.

“Oh good!” exclaims Mike. “You’re showing Marcus some mouse work!”

Navya turns to Mike and smiles. “Yes, throwing him right into the deep end!”

“It’s wild,” adds Marcus.

“Listen,” Mike says to Navya. “I really think it’s time to submit the manuscript. We could go on with these experiments forever. Better to just get it submitted and see what the reviewers have to say.” ‘m really concerned about figure four. I don’t think we’ve got it. I get that catalase is up in the neurons, but I think just be some sort of overcompensation. I think we’ve gotta show a stronger downstream effect.”

Navya removes her gloves and throws them forcefully into the trash bin beside her.

“Seriously? Mike, we don’t have it yet. It’s not enough to show that the catalase is up in the neurons. That could just be some sort of compensatory effect. We’ve gotta show that it actually directly increases tau pathology.”

“I know, I know” Mike replies, timidly. “But, I just… That could take another year, and the lab really needs this publication.”

“It won’t take a year, Mike,” Navya replies despondently. You think I don’t want a publication? I need it for my K99. But the data isn’t there yet, and you know it.”

Mike stands there, silent for a second. Marcus tries to look away, wishing he could leave the bay without it being too obvious.

“I just…” Mike stammers. “Let’s see what the reviewers say.” How do we know that the peroxisomes are causing the behavioral defects? I just think we need to connect those dots a bit more. Just one or two more experiments. I promise.”

“I’m gonna flip, Mike. I really am. How do we know that the peroxisomes are causing the tau pathology? Answer that for me. Please. I’m working around the clock right now. You know that I am. Let me just get the data. It won’t be that much longer.”

“Ok,” Mike replies. “But just… Let me know when you get the results from this experiment. We’ll take a look and discuss again.”

“Fine. But I’m not submitting until I’m confident that the story is correct.”

“Navya, it’s not your decision to make.”

“Well, if you make it without me, I’m gonna quit and go become a bartender or something.”

“Navya.”

“Mike.”

Mike takes a deep breath and exhales slowly. He suddenly notices Marcus again.

“We’ll discuss again after you get the results,” Mike concludes.

“Fine,” Navya replies.

Mike turns and walks out of the bay. Navya continues to stare in the direction that Mike was previously standing.

“The mouse seems to be gasping for air,” Marcus says softly.

“Shit” Navya exclaims, snapping herself back into the moment. “Ok, time to perfuse.”

“Perfuse?” asks Mike.

“Yeah,” replies Navya, pulling the anesthetized mouse from the cage. “It’s pretty wild.”

4/14/26, 3:30pm Read Post »

4/18/26 9:30pm

Navya is at a semi-crowded bar, a glass of scotch her right hand. She’s wearing a black shirt and jeans, sitting on a stool at the bar, deep in conversation with Mia, who has on a red shirt and black slacks.


“I know, right?” Mia interjects. “Dr. Robby is such an asshole this season.”


“Yeah,” Navya replies. “Although I do appreciate the honesty of it. He’s a good man, but his job is stressful as hell. And he’s got lots of issues, like we all do.”


“True,” replies Mia. “But people are so distrustful of doctors these days, and everyone’s watching that show. Dr. Robby was the one doctor we all had faith in.”


“A fictional doctor,” adds Navya. 


“Yes, fictional,” agrees Mia. “But that’s how we learn about things. Through art.” 


“Yes,” Navya adds, taking a moment to think. “But that’s why it’s so important to portray people accurately, especially health care workers. We build them up into these perfect saviors, and then when the public realizes that’s not true, they feel lied to. At the end of the day, doctors and scientists are just normal people who are trying their best. I say let’s rip the bandaid off and let the public see who they really are.”  


“You think you’re normal?” Mia replies.

”Very funny…” Navya starts to answer. However, their conversation is abruptly interrupted by a tall guy in a dress shirt and jeans, who leans between them to flag down the bartender.


“Can we help you?” Mia asks.


“I’m just trying to get a drink,” the guy replies without looking at her. 


“And I’m just trying to be a human being who other people realize exists in the world,” replies Mia.


“What?” the guy replies, finally looking in her direction.


“Hey, could you also buy me a drink?” Mia asks him, doing her best impression of demure.


The guy looks Mia up and down. His posture settles, and he smiles at her.


“Sure. What would you like?” 

 

Mia thinks for a second. “Can you get me a martini with a splash of Get the Fuck Out our Way! We’re Trying to Have a Fucking Conversation Here! What the Hell is Wrong with You?!”


The guy jumps. “Jesus. I was just… What the hell is wrong with me? What the hell is wrong with you?!”


The guy backs away, still looking at Mia in disbelief. He then walks over to the other side of the bar.


“That was kinda harsh,” comments Navya. “He was just trying to get a drink.”


“Nah, fuck him,” replies Mia. “He stepped right in-between us.”


At that moment, another guy, similarly dressed as the first guy, approaches Navya.


“I’m sorry about my friend,” the guy says to Navya and MIa, shouting to be heard over the noise of the bar. “He’s just oblivious. Does shit like that all the time.”


“That’s ok,” replies Navya. “It’s just that we were in the middle of a conversation.”


“Right…” replies the guy. “…and I’ll leave you to it. I just wanted to apologize about my friend.”


But as the guy starts to leave, Mia shouts at him.


“Hold up! Are you single?”


“Mia!!” Navia shouts at her.


The guy turns back to face them. 


“Um, yeah, I am,” the guy replies hesitantly.


Mia gestures to Navya. “You should meet my friend Navya. She’s a scientist!”


“Oh wow,” the guy responds, clearly impressed. “What kind of scientist?”


“She studies Alzheimer’s disease!” exclaims Mia.


“Wow, that’s so cool!”


Navya is clearly uncomfortable.


“It’s just a job,” she replies. 


So are you, like, a doctor?”


“Yeah, technically,” Navya replies. “I’m a PhD though, not an MD. I can’t prescribe any drugs.”


“Well that’s a shame. What’s your PhD in?”


“Pharmacology,” replies Navya.


“So you’re, like, a pharmacist?” asks the guy.


“No, not at all. More like drug discovery research.”


“Oh, cool. Do you teach?” the guy asks.


“Not a day in my life,” replies Navya. “Just research.”

“Cool!” replies the guy. “Are you close to finding a cure? Alzheimer’s is such an awful disease.”

“Me? No. But the field is making a lot of progress.”


Mia interjects. “She studies peroxisomes!”


“What the hell is a peroxisome?” the guy asks her.


“I have no idea!” replies Mia.


“That’s why I just tell people I study Alzheimer’s disease,” adds Navya. “Anyway, it was nice talking to you.”


The guy shuffles in place, not taking the hint. 


“What was your name? Nadia?” 


Navya is starting to look annoyed. “No, Navya.” 


“Na-vy-a,” the guy repeats, spelling it out slowly. “Cool. What part of India are you from?” 


“I’m from New Jersey,” Navya replies.


“Oh.”  


All three just look at each other for a beat.


“Ok,” Mia finally interjects. “Time to run along!”


“Oh, ok,” the guy responds. “It was nice to meet you.”


“Nice to meet you, too,” Navya responds.


The guy walks away. Mia waits until he’s out of earshot before she speaks.


“You’re way too picky,” Mia suggests. “He was hot!”


“Well, maybe I want more than just hot.” replies Navya.


“What did you say about Dr. Robby?” Mia asks. “Stop trying to build men up into perfect saviors. They’re just normal people. Less than that sometimes. Just pick a cute one and have some fun.”


“I’m not looking for fun,” responds Navya, incredulously. “I’m looking for the real deal!”


“In this city?!” replies Mia. “Good luck with that!”


Navya takes one last sip of her scotch, which is mostly just ice now. She then waves her hand to flag down the bartender.


“I need another drink,” she announces. 


“Now we’re talking!” Mia agrees.

4/18/26 9:30pm Read Post »

4/22/26 1:10pm

Mike is sitting in his office, sitting at his desk, facing his computer. He’s currently talking to two Maria and Jason over Zoom.

“I know,” Mike says, clearly exasperated. “I’m trying to make cuts, but it’s hard. We’re in the middle of a lot of important experiments right now.”

“Dr. Fein, you’re in a significant overrun.” Jason states emphatically. “You’ve either gotta lay someone off or cut back on the expenses. Or ideally, both.”

“I’ve got two grants that are going to be reviewed this month,” Mike responds. “Let’s just wait and see what their scores are, and then I’ll make some decisions.”

“Unfortunately, the scores aren’t going to tell us much,” Jason argues. “Maybe if you get 5th percentile or something. With the new rules at NIH, it’s almost impossible to know if a grant will be funded based on the scores alone.”

“Maria, how much is left on the R21?” Mike asks.

“$20,500,” replies Maria. “But I’ve got your both salary and Tomoko’s salary allocated 50% on that. If we include the OTPS and animal costs we have allocated on that, the R21 will only last another 3 months. After that, everything will be coming out of your startup, and that’ll last less than a year with the entire lab’s budget on it.”

“I’m going to get an R01 soon,” Mike pleads. “I’ve got to. I just wish I could get Navya’s paper published. The reviewers are killing me on my lack of productivity since I started the lab.”

“About Navya,” Jason says delicately. “Her re-appointment is set for June. And frankly, I don’t know if the institute can go through with it given your current funding situation.”

Mike rubs his eyes with his thumb and index finger.

“Ok Ok,” responds Mike. “I’ll cut back on the expenses. I don’t know how we’re going to accomplish anything, but I’ll cut back. Just give me a few days to figure it out, and I’ll tell the lab at lab meeting on Monday.”

“It’s going to have to be a significant cut-back, Dr. Fein,” Jason says. “Otherwise, someone will have to go. Chris is a grad student, and Tomoko just started her new appointment. So it’ll probably have to be Navya. It’s just not sustainable with three lab members and your current level of spending.”

“Ok. I know,” Mike replies. “Just give me some time. Let’s meet again next week.”

“Ok,” responds Jason. “But next week we have to make some final decisions.”

“Yes, next week,” Mike replies. “For sure.”

And with that, Mike thanks Jason and Maria and ends the Zoom meeting. But he keeps staring at the background screen on his computer, lost in thought.

4/22/26 1:10pm Read Post »

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