4/13/26, 7:45pm

It’s dark outside, but the fluorescent lights shine bright inside the lab. The lab is made up of four separate bays, each containing two adjacent benches. At the beginning of each bench, next to the window, is a desk, with a computer or laptop sitting on top. There’s a short chair in front of each desk and a tall chair in front of each bench. There are a few large pieces of equipment. A large white slide scanner on the bench against the far wall, and a large black HPLC on the righthand bench in the second bay of the lab when you enter the door. But mostly, the benches and the shelves above them are just full of bottles and boxes of pipette tips and various reagents. It’s a messy scene, but not because things are dirty or out of place. This is clearly a lab that is in heavy use. 

There’s only one lab member present at the moment. Navya. She’s sitting on the tall chair, in the second to last bay, hovering over the bench. She’s wearing a turquoise hoodie, pipette in hand. 

Navya’s benchtop is littered with bottles full of clear liquids, colorful tube racks lined with small and large tubes, two open cardboard kit boxes with reagents scattered about, a small beaker half full of discarded pipette tips, and lots more.

Navya has large black headphones on and doesn’t notice as Mike walks into the lab. Mike is wearing a dress shirt, untucked from his dark jeans. Coffee mug in hand. A lab no-no, but it’s late, and Mike doesn’t want to be too far away from his coffee. 

Mike approaches Navya’s bench slowly.

“Navi,” he says softly. No response.

He waves a hand in the air. Still no response.

“Navi,” he says louder. No response.

Suddenly, Navya sees Mike in her peripheral vision and jerks up, nearly falling off of her chair.

“Shit. You scared me.”

“I know,” Mike replies. “Sorry, I tried to…”

“I thought you’d left,” Navya says, as she lowers her headphones onto her neck.

“Just to grab some food. Grant’s due tomorrow. It’s gonna be a late night.”

“Ugh. That sucks. I’m almost done. I’m meeting a friend at…” Navya glances at her watch. “Shit!”

Navya abruptly stands up from the chair and starts scrambling. She discards her pipette tip and closes the open tubes. She packs up the kits, runs them over to the fridge, and shoves them in. She throws her tube rack full of small tubes into a small incubator on the adjacent bench. All while Mike is standing there, coffee mug still in hand.

“Bad time?” asks Mike.

“Sorry. It’s a new friend. I don’t want to be late. Well, I mean I don’t want to be too late.”

“No problem,” Mike responds.

“Was it something important?”

“No,” Mike says, half to himself. “Well, maybe. But it can wait.”

“Ok, sorry.”

Navya grabs her coat from her desk, throws her laptop in her backpack, and hurries past Mike.

“We’ll be alright,” Mike says quietly. “I have a good feeling about this one.”

“Great!” Navya responds, running out of the lab. “See you tomorrow!”

“Yes, see you tomorrow,” Mike says, his voice trailing off. He takes one last sip from his coffee mug and walks out of the now empty lab.

4/13/26, 7:45pm Read Post »

4/14/26, 10:25am

The lab is full today, with five lab members spread about the lab, some sitting at their desks, some working at their benches. 

Navya is back in her bay, sitting at her desk, typing away at her computer. Directly behind her, sitting back to back with her, is Chris, wearing a blue t-shirt, currently scrolling through his iPhone. 

“Did you hear what Trump posted?” Chris asks. “Such a jackass.”

“I really don’t want want to know.” Navya responds.

“He called the Pope weak on crime! I mean, for christ’s sake…literally!” 

“He just talks. I don’t know why you even pay attention anymore,” Navya responds. 

“Well, you know what they say about train crashes,” Chris says, still scrolling. “Except in this case, we’re all the passengers, and he’s the conductor.” 

Navya pulls up a powerpoint presentation on her computer.

“Hey, did you get that script working?” Navya asks.

“Oh yeah. ChatGPT baby. It runs like a charm now.”

“Great,” Navya exclaims. “What were the results?”

“Nothing significant.” Chris shrugs, closing the current app on his phone and opening another. 

“Damnit. Are you sure? What was the exact analysis you ran? Maybe…” 

At that moment, Ling steps into the bay wearing a labcoat. She’s followed close behind by a young man who is also wearing a labcoat…although he seems much less comfortable in the labcoat compared to Lin.

“Navi, Chris, I’d like to introduce you to Marcus.” 

Navya looks up from her computer. Chris keeps staring at his phone. 

“Hi Marcus, nice to meet you,” says Navya. 

“Yeah, good meeting you,” Chris chimes in.

“Marcus is the undergrad that Dr. Fein mentioned in lab meeting. I’m showing him around today, but we’re still figuring out who he should work with. Do you guys need help with anything?” 

“How do you feel about mousework?” Navya asks.

“Me?” Marcus replies shyly. “I guess that’s ok. Like living mice?”

Chris finally looks up from his phone. “Yeah, that’s the idea. Well, living right now. Less so once it’s time to collect their brains.” 

“Their brains?” asks Marcus.

“Yeah, that is how you study Alzheimer’s disease,” replies Chris. “You kinda have to look at the brain.”

“Oh,” replies Marcus nervously. “That makes sense.”

There’s a pause. Marcus is thinking, and Chris is happy to let him process the situation.

“Do I have to, like, touch them?” asks Marcus.

“Not with your hands, but we will need to use your teeth to get their heads off.”

“Chris!!” shouts Navya. “That really isn’t funny.”

Navya gets up and approaches Marcus.

“I assure you, we follow all of our animal protocols to the letter. You can join me this afternoon. Don’t worry…I’ll do all the mouse handling. You can just watch for now. If you feel comfortable later, you can help with some of the procedures.”

“Yeah, that sounds good. My mom is gonna flip when I tell her I worked with mice.”

“Yeah, it’s pretty interesting. And I’m really sorry about Chris. He’s a little off.”

“Welcome to the lab, Marcus!” shouts Chris.

“Um, thanks…” replies Marcus, as him and Ling walk over to the next bay.

“What the hell is wrong with you?” Navya chastises Chris, as she sits back down at her desk. 

“Sorry,” Chris responds. “I couldn’t resist.”

4/14/26, 10:25am Read Post »

4/14/26, 3:30pm

Navya and Marcus are in the back of the lab, next to the fume hood. Both are wearing lab coats and purple latex gloves. Navya places some blue pads down on the far bench and lays out some dissection tools. Marcus is bending down, his eyes staring directly into a small cage, watching two black mice run around.

“This is so wild.” Marcus says. “My mom’s gonna flip.”

“So where are you from, Marcus?” Navya asks, as she continues to prepare for the dissection.

“North Carolina. I actually spent a summer working in a lab at Duke when I was in High School. But they didn’t have any mice!”

“And how are you liking the big city?” Navya asks. “Quite the change from North Carolina.”

“Oh yeah,” Marcus replies. “NYC is built different, for sure. But I love it here. NYU was my top choice.”

“That’s great,” replies Navya. “Ok, I think we’re ready to start.”

Marcus stands up straight again and backs away from the mice.

“So we’re just gonna, like, kill them? Will they feel it?”

Navya removes the water bottle from the cage and places it down on the bench. Then she takes the cage lid off and places it on the bench. Then she tilts up the metal wire portion that holds the mouse food, so that she can reach the mice.

“We anesthetize them first,” Navya says, grabbing a mouse by its tail and placing it onto the metal wiring. “The small prick that it’s about to feel from this needle is the most pain it will feel.”

While still holding the mouse’s tail with her right hand, Navya scruffs the mouse with her left hand, placing her thumb and the knuckle of her index finger on the mouse’s neck and pinning it against the cage. Then she pinches the skin of the mouse’s neck tightly, grabs the tail with her right pinky, and lifts up the mouse, all in one swift motion. The mouse tries to wiggle it’s head left and right, but it’s completely immobilized.

“Wild,” Marcus repeats.

“You know, I spent all of grad school refusing to do mouse work,” Navya says, now picking up a syringe off the bench with her right hand. “I’m actually a vegan!”

“What changed?” asks Marcus.

“The science,” replies Navya. “I discovered an interesting signal in the entorhinal cortex of postmortem human brains. That’s a region that’s affected early in Alzheimer’s disease. I wanted to study if that signal is responsible for the Alzheimer’s pathology the develops in that region. But cells don’t have brain regions, so the only way to test my hypothesis is in mice.”

Navya carefully insert the needle of the syringe into the mouse’s abdomen. The mouse lets out a quick squeal.

“I’m sorry, buddy” Navya says to the mouse. Then she presses down on the syringe, injecting the ketamine/xylazine solution into the mouse’s abdomen. Navya withdraws the needs, places the syringe back down on the bench, and lifts up the wiring again. She then places her hand back into the cage and let’s the mouse go; the mouse quickly jumps forward and runs around the cage again.

“Now what?” asks Marcus.

“Now we wait,” replies Navya.

At that moment, Mike appears at the end of the bay.

“Oh good!” exclaims Mike. “You’re showing Marcus some mouse work!”

Navya turns to Mike and smiles. “Yes, throwing him right into the deep end!”

“It’s wild,” adds Marcus.

“Listen,” Mike says to Navya. “I really think it’s time to submit the manuscript. We could go on with these experiments forever. Better to just get it submitted and see what the reviewers have to say.” ‘m really concerned about figure four. I don’t think we’ve got it. I get that catalase is up in the neurons, but I think just be some sort of overcompensation. I think we’ve gotta show a stronger downstream effect.”

Navya removes her gloves and throws them forcefully into the trash bin beside her.

“Seriously? Mike, we don’t have it yet. It’s not enough to show that the catalase is up in the neurons. That could just be some sort of compensatory effect. We’ve gotta show that it actually directly increases tau pathology.”

“I know, I know” Mike replies, timidly. “But, I just… That could take another year, and the lab really needs this publication.”

“It won’t take a year, Mike,” Navya replies despondently. You think I don’t want a publication? I need it for my K99. But the data isn’t there yet, and you know it.”

Mike stands there, silent for a second. Marcus tries to look away, wishing he could leave the bay without it being too obvious.

“I just…” Mike stammers. “Let’s see what the reviewers say.” How do we know that the peroxisomes are causing the behavioral defects? I just think we need to connect those dots a bit more. Just one or two more experiments. I promise.”

“I’m gonna flip, Mike. I really am. How do we know that the peroxisomes are causing the tau pathology? Answer that for me. Please. I’m working around the clock right now. You know that I am. Let me just get the data. It won’t be that much longer.”

“Ok,” Mike replies. “But just… Let me know when you get the results from this experiment. We’ll take a look and discuss again.”

“Fine. But I’m not submitting until I’m confident that the story is correct.”

“Navya, it’s not your decision to make.”

“Well, if you make it without me, I’m gonna quit and go become a bartender or something.”

“Navya.”

“Mike.”

Mike takes a deep breath and exhales slowly. He suddenly notices Marcus again.

“We’ll discuss again after you get the results,” Mike concludes.

“Fine,” Navya replies.

Mike turns and walks out of the bay. Navya continues to stare in the direction that Mike was previously standing.

“The mouse seems to be gasping for air,” Marcus says softly.

“Shit” Navya exclaims, snapping herself back into the moment. “Ok, time to perfuse.”

“Perfuse?” asks Mike.

“Yeah,” replies Navya, pulling the anesthetized mouse from the cage. “It’s pretty wild.”

4/14/26, 3:30pm Read Post »

4/18/26 9:30pm

Navya is at a semi-crowded bar, a whisky-based cocktail in her right hand. She’s dressed in black, sitting on a stool at the bar, deep in conversation with Mia, also in black.


“I know, right,” Mia interjects. “Dr. Robby is such an asshole this season.”


“I get it,” Navya replies. “His job is stressful as hell, and he’s got lots of issues, like we all do. But people are so distrustful of the healthcare industry these days, and everyone is watching this frickin’ show right now. Dr. Robby was the one person people had faith in.”


“But that’s the point,” Mia argues. “There are no heroes. There are just real people trying their best!”


“Sure,” replies Navya, choosing her words carefully. “But people aren’t ready to accept that yet!”


Navya and Mia’s conversation is interrupted by a tall guy in a dress shirt and jeans, who leans between them to flag down the bartender.


“Can we help you?” Mia asks.


“Sorry,” the guy replies without looking at her. “I’m just trying to get a drink.”


“And I’m just trying to be a human being who other people realize exists in the world,” replies Mia.


“What?” the guy replies, still trying to flag down the bartender.


Navya taps the guy on the shoulder. He turns and looks at her.


“Hey, could you buy me a drink?” Navya asks him, doing her best impression of demure.


The guy looks Navya up and down. His posture settles, and he smiles at her.


“Sure. You’re hot. What’s your name.”


“Navya”


 “Na-vy-a,” the guy repeats slowly. “Wow. Are you from India?”


“No,” replies Navya. “New Jersey.”


“Oh,” the guy says to himself, pausing for a moment. “Well what would you like to drink?” Navya thinks for a second. “Can you get me a martini with a splash of Get the Fuck Out our Way! We’re Trying to Have a Fucking Conversation Here! What the Hell is Wrong with You?!”


The guy jumps. “Jesus. I was just… What the hell is wrong with me? What the hell is wrong with you?”


The guy backs away, still looking at Navya in disbelief. He then walks over to the other side of the bar.


“Nice,” comments Mia.


“Was that too harsh?” asks Navya. “He was just trying to get a drink.”


“Nah, fuck him,” replies Mia. “That was perfect. I loved it.”


At that moment, another guy, this time in a green sweater and slacks approaches them. He taps Mia on the shoulder.


“Caleb!” exclaims Mia. “Where have you been!”


“Sorry,” replies Caleb. “The trains are a mess. I waited twenty minutes for the 1.”


“All good,” replies Mia. “Where’s Jake?”


“He wasn’t feeling well. I left him on the couch watching Love Island.”


Mia turns to Navya. “Caleb, this is the new friend I was telling you about. Navya, meet Caleb. Caleb, Navya.”


“Nice to meet you,” Navya shouts to Caleb, making sure he can hear her over the noise in the bar.


“You’re the scientist, right?!” exclaims Caleb.


“Yes, I guess I am,” replies Navya.


“That’s so cool!” Caleb shouts.


Caleb looks around, grabs am empty bar stool, and sits down between Navya and Mia, but far enough back so that all three can converse.


“Where do you work?” asks Caleb.


“NYU,” replies Navya.


“Oh, cool! I love the village.”


“Actually, most of the research at NYU is done on the east side, around 33rd street.”


“Oh, cool,” replies Caleb. “I didn’t know that. So are you like a doctor?”


“Yeah, technically,” Navya replies. “I’m a PhD, not an MD. I can’t prescribe any drugs.”


“Well that’s a shame. What did you get your PhD in?”


“Pharmacology,” replies Navya.


“So you’re a pharmacist?” asks Caleb.


“No, not at all. More like drug discovery. But really, I just research basic disease mechanisms of Alzheimer’s disease”


“Alzheimer’s?! That’s amazing. My aunt had Alzheimer’s. It’s such a horrible disease.”


“Yeah, it is,” replies Navya.


“So, like, are you close to a cure? That would be so great.”


“Me? No. But the field is making a lot of progress.”


Mia interjects. “Navya studies peroxisomes!”


“The hell is a peroxisome?” Caleb asks.


“I have no idea!” replies Mia.


“That’s why I just tell people I study Alzheimer’s disease,” adds Navya. “Anyway, what do you do Caleb?”


“Oh, nothing as important as you! I work in fashion. Wait, how do you study Alzheimer’s disease? Like, what do you do every day?”


“I run experiments,” Navya says. “Mostly in mice. Sometimes in cells.”


“Mice! Oh my god, that’s crazy.”


“It really isn’t,” replies Navya.


Navya takes one last swig of her drink, which is now mostly just ice. She holds the glass to her mouth for an extra moment to extract all of the remaining liquid.


“I think I’m gonna go,” Navya says, as she puts the glass down on the bar. “I need a good night’s sleep tonight.”


“What? No!” Mia yells. “It’s still early!”


“I know,” replies Navya. “But I have a poster presentation next week, and it’s not even close to finished. I’m gonna have to work on it all day tomorrow, and I don’t want to be tired and hungover.”


“A poster?” asks Caleb, confused. “Like a collage?”


“No, nothing like that,” Navya says, as she stands up and reaches out to shake Caleb’s hand. “Nice to meet you Caleb.”


“Oh my god, soooo nice to meet you,” replies Caleb, giving Navya’s hand a double handed squeeze. “Good luck with the Alzheimer’s research!”


Navya grabs her coat and hugs Mia.


“I’m so glad you could come out” Mia says in Navya’s ear. “Are we still on for the MOMA next week?”


“I think so,” replies Navya as she finishes hugging Mia and leans back. “I have to see how things go in the lab. But I’ll do my best!”


“Ok, love you!” Mia shouts loudly.


“Love you too,” replies Navya. “Don’t stay out too late!”


“Fuck that,” Mia says. “Tonight’s gonna be a rager!”


“Alright, well then stay safe at least.”


“Don’t worry, I’ll protect her!” Caleb interjects confidently.


“See, who needs Dr. Robby when I’ve got Caleb?!” Mia exclaims.


“Oh my god, I loooove Dr. Robby.” Caleb replies.


“Me too,” Mia agrees. “But he’s such an asshole this season.”


And with that, Navya walks away, leaving Mia and Caleb to continue the conversation without her.

 

4/18/26 9:30pm Read Post »

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